Publications | Gliomics lab

2023

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.

Michael-John Dolan*, Martine Therrien*, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy, Cassandra M. White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan Nir Hacohen, Bradley E. Bernstein, Christopher K. Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B. Epstein, Evan Z. Macosko, Beth Stevens. * These authors contributed equally and are listed in alphabetical order. Nature Immunology, (2023) https://doi.org/10.1038/s41590-023-01558-2

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states

Vahid Gazestani, Tushar Kamath, Naeem M. Nadaf, SJ Burris, Brendan Rooney, Antti Junkkari, Charles Vanderburg, Tuomas Rauramaa, Martine Therrien, Matthew Tegtmeyer, SannaKaisa Herukka, Abdulraouf Abdulraouf, Samuel Marsh, Tarja Malm, Mikko Hiltunen, Ralda Nehme, Beth Stevens, Ville Leinonen, Evan Z. Macosko. Cell 2023 PMID: 37774681

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

Nicolas Wieder, Juliana Coraor Fried, Choah Kim, Eriene-Heidi Sidhom, Matthew R. Brown, Jamie L. Marshall, Carlos Arevalo, Moran Dvela-Levitt, Maria Kost-Alimova, Jonas Sieber, Katlyn R. Gabriel, Julian Pacheco, Clary Clish, Hamdah Shafqat Abbasi, Shantanu Singh, Justine Rutter, Martine Therrien, Haejin Yoon, Zon Weng Lai, Aaron Baublis, Renuka Subramanian, Ranjan Devkota, Jonnell Small, Vedagopuram Sreekanth, Myeonghoon Han, Donghyun Lim, Anne E. Carpenter, Jason Flannick, Hilary Finucane, Marcia C. Haigis, Melina Claussnitzer, Eric Sheu, Beth Stevens, Bridget K. Wagner, Amit Choudhary, Jillian L. Shaw, Juan Lorenzo Pablo, Anna Greka. Cell Metabolism (2023) PMID: 37075753

Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALS

Francesco Limone, Daniel A. Mordes, Alexander Couto, Brian J. Joseph, Jana M. Mitchell, Martine Therrien, Sulagna Dia Ghosh, Daniel Meyer, Yingying Zhang, Melissa Goldman, Laura Bortolin, Inma Cobos, Irena Kadiu, Steven A. McCarroll, Beth Stevens, Olli Pietiläinen, Aaron Burberry, Kevin Eggan. BioRxiv

doi: https://doi.org/10.1101/2021.07.12.452054

2022

A resource for generating and manipulating human microglial states in vitro

Michael-John Dolan*, Martine Therrien*, Saša Jereb, Tushar Kamath, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy, Cassandra M. White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E. Bernstein, Christopher K. Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B. Epstein, Evan Z. Macosko, Beth Stevens. BioRxiv

doi: https://doi.org/10.1101/2022.05.02.490100

Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases. T. Yvanka de Soysa*, Martine Therrien*, Alicia C. Walker, Beth Stevens. * These authors contributed equally. Seminars in Immunology, (2022) https://doi.org/10.1016/j.smim.2022.101651

2020

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.

Wertz, M. H., Mitchem, M. R., Pineda, S. S., Hachigian, L. J., Lee, H., Lau, V., Powers, A., Kulicke, R., Madan, G. K., Colic, M., Therrien, M., Vernon, A., Beja-Glasser, V. F., Hegde, M., Gao, F., Kellis, M., Hart, T., Doench, J. G., & Heiman, M. (2020). Neuron, https://doi.org/10.1016/j.neuron.2020.01.004

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.

Lee, H., Fenster, R. J., Pineda, S. S., Gibbs, W. S., Mohammadi, S., Davila-Velderrain, J., Garcia, F. J., Therrien, M., Novis, H. S., Gao, F., Wilkinson, H., Vogt, T., Kellis, M., LaVoie, M. J., & Heiman, M. (2020). Neuron, https://doi.org/10.1016/j.neuron.2020.06.021

2019

Exome sequencing of sporadic childhood‐onset schizophrenia suggests the contribution of X‐linked genes in males.

Ambalavanan, A., Chaumette, B., Zhou, S., Xie, P., He, Q., Spiegelman, D., Dionne‐Laporte, A., Bourassa, C. V., Therrien, M., Rochefort, D., Xiong, L., Dion, P. A., Joober, R., Rapoport, J. L., Girard, S. L., & Rouleau, G. A. (2019). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(6), 335–340. https://doi.org/10.1002/ajmg.b.32683

2016

FET proteins regulate lifespan and neuronal integrity.