2026
Microglia in systemic neuroimmune communication: functions beyond phagocytosis
Anabella Ayelen Di Pietro , Sharon Powley , Elisa Perciballi , Meredith Stewart, Martine Therrien*, Nicole Scott-Hewitt*. * co-corresponding author. Trends in Immunology, (2026)
2025
!!!Some of our most frequently used protocols are now on protocol.io !!!
Differentiation of Induced Pluripotent Stem Cells (iPSCs) into Microglia-like cells (iMG)
Elisa Perciballi, Micheal John Dolan, Martine Therrien, Beth Stevens, Protocol.io 2025
https://dx.doi.org/10.17504/protocols.io.ewov11rw2vr2/v1
Transduction of Microglia-like cells (iMG) with lentivirus
Elisa Perciballi, Saša Jereb, Martine Therrien, Beth Stevens, Protocol.io 2025
https://dx.doi.org/10.17504/protocols.io.6qpvrw1xolmk/v1
2023
Michael-John Dolan*, Martine Therrien*, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy, Cassandra M. White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan Nir Hacohen, Bradley E. Bernstein, Christopher K. Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B. Epstein, Evan Z. Macosko, Beth Stevens. * These authors contributed equally and are listed in alphabetical order. Nature Immunology, (2023) https://doi.org/10.1038/s41590-023-01558-2
Vahid Gazestani, Tushar Kamath, Naeem M. Nadaf, SJ Burris, Brendan Rooney, Antti Junkkari, Charles Vanderburg, Tuomas Rauramaa, Martine Therrien, Matthew Tegtmeyer, SannaKaisa Herukka, Abdulraouf Abdulraouf, Samuel Marsh, Tarja Malm, Mikko Hiltunen, Ralda Nehme, Beth Stevens, Ville Leinonen, Evan Z. Macosko. Cell 2023 PMID: 37774681
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
Nicolas Wieder, Juliana Coraor Fried, Choah Kim, Eriene-Heidi Sidhom, Matthew R. Brown, Jamie L. Marshall, Carlos Arevalo, Moran Dvela-Levitt, Maria Kost-Alimova, Jonas Sieber, Katlyn R. Gabriel, Julian Pacheco, Clary Clish, Hamdah Shafqat Abbasi, Shantanu Singh, Justine Rutter, Martine Therrien, Haejin Yoon, Zon Weng Lai, Aaron Baublis, Renuka Subramanian, Ranjan Devkota, Jonnell Small, Vedagopuram Sreekanth, Myeonghoon Han, Donghyun Lim, Anne E. Carpenter, Jason Flannick, Hilary Finucane, Marcia C. Haigis, Melina Claussnitzer, Eric Sheu, Beth Stevens, Bridget K. Wagner, Amit Choudhary, Jillian L. Shaw, Juan Lorenzo Pablo, Anna Greka. Cell Metabolism (2023) PMID: 37075753
Francesco Limone, Daniel A. Mordes, Alexander Couto, Brian J. Joseph, Jana M. Mitchell, Martine Therrien, Sulagna Dia Ghosh, Daniel Meyer, Yingying Zhang, Melissa Goldman, Laura Bortolin, Inma Cobos, Irena Kadiu, Steven A. McCarroll, Beth Stevens, Olli Pietiläinen, Aaron Burberry, Kevin Eggan. BioRxiv
doi: https://doi.org/10.1101/2021.07.12.452054
2022
A resource for generating and manipulating human microglial states in vitro
Michael-John Dolan*, Martine Therrien*, Saša Jereb, Tushar Kamath, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy, Cassandra M. White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E. Bernstein, Christopher K. Glass, Ville Leinonen, Mathew Blurton-Jones, Feng Zhang, Charles B. Epstein, Evan Z. Macosko, Beth Stevens. BioRxiv
doi: https://doi.org/10.1101/2022.05.02.490100
Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases. T. Yvanka de Soysa*, Martine Therrien*, Alicia C. Walker, Beth Stevens. * These authors contributed equally. Seminars in Immunology, (2022) https://doi.org/10.1016/j.smim.2022.101651
2020
Wertz, M. H., Mitchem, M. R., Pineda, S. S., Hachigian, L. J., Lee, H., Lau, V., Powers, A., Kulicke, R., Madan, G. K., Colic, M., Therrien, M., Vernon, A., Beja-Glasser, V. F., Hegde, M., Gao, F., Kellis, M., Hart, T., Doench, J. G., & Heiman, M. (2020). Neuron, https://doi.org/10.1016/j.neuron.2020.01.004
Lee, H., Fenster, R. J., Pineda, S. S., Gibbs, W. S., Mohammadi, S., Davila-Velderrain, J., Garcia, F. J., Therrien, M., Novis, H. S., Gao, F., Wilkinson, H., Vogt, T., Kellis, M., LaVoie, M. J., & Heiman, M. (2020). Neuron, https://doi.org/10.1016/j.neuron.2020.06.021
2019
Ambalavanan, A., Chaumette, B., Zhou, S., Xie, P., He, Q., Spiegelman, D., Dionne‐Laporte, A., Bourassa, C. V., Therrien, M., Rochefort, D., Xiong, L., Dion, P. A., Joober, R., Rapoport, J. L., Girard, S. L., & Rouleau, G. A. (2019). American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(6), 335–340. https://doi.org/10.1002/ajmg.b.32683
2016
FET proteins regulate lifespan and neuronal integrity.
Therrien, M., Rouleau, G. A., Dion, P. A., & Parker, J. A. (2016). Scientific Reports, 6(1), 25159. https://doi.org/10.1038/srep25159
Aaron, C., Beaudry, G., Parker, J. A., & Therrien, M. (2016). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5b05432
2013
Deletion of C9ORF72 Results in Motor Neuron Degeneration and Stress Sensitivity in C. elegans.
Therrien, M., Rouleau, G. A., Dion, P. A., & Parker, J. A. (2013). PLoS ONE, 8(12), e83450. https://doi.org/10.1371/journal.pone.0083450
2012
Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio.
Vaccaro, A., Patten, S. A., Ciura, S., Maios, C., Therrien, M., Drapeau, P., Kabashi, E., & Parker, J. A. (2012). PLoS ONE, 7(7), e42117. https://doi.org/10.1371/journal.pone.0042117
Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models.
Stochmanski, S. J.*, Therrien, M.*, Laganière, J., Rochefort, D., Laurent, S., Karemera, L., Gaudet, R., Vyboh, K., Meyel, D. J. V., Cristo, G. D., Dion, P. A., Gaspar, C., & Rouleau, G. A. (2012). Human Molecular Genetics, 21(10), 2211–2218. https://doi.org/10.1093/hmg/dds036